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11 Nov 2019
Experiment 7: Effect of Buffer Solutions on pH Stability creases 4. When a person exercises, muscle contractions produce lactic acid. Moderate in in lactic acid can be handled by the blood buffers without decreasing the pH of blood However, excessive amounts of lactic acid can overload the blood buffer system in the lowering of the blood pH. A condition called acidosis is diagnosed if the blood phH falls to 7.35 or lower. Assume the primary blood buffer system is the carbonate buffer system shown below. Calculate what happens to the [H,co,]/[HCO, ] ratio when the pHi esulting decreases from 7.40 to 7.35. H,CO3(aq) + H20(1): HC03-(aq) + H30'(aq) Kai = 43 x 10-7 5. Phosphate ions are abundant in cells, both as the ions themselves and as important sub- stituents on organic molecules. Most importantly, the pK, for the H2PO, ion is 7.20, which is very close to the normal pH in the body. H,P04-(aq) + H20(1) HP042-(aq) + H,0"(aq) a. What should the ratio [HPO,2]/[H,P0,] be to control the pH at 7.4? b. A typical total phosphate concentration in a cell, [HPO, ] [H2PO,], is 2.0 x 10-2 M. what are the concentrations of HP042-and H2 PO, at pH 7.4? 142
Experiment 7: Effect of Buffer Solutions on pH Stability creases 4. When a person exercises, muscle contractions produce lactic acid. Moderate in in lactic acid can be handled by the blood buffers without decreasing the pH of blood However, excessive amounts of lactic acid can overload the blood buffer system in the lowering of the blood pH. A condition called acidosis is diagnosed if the blood phH falls to 7.35 or lower. Assume the primary blood buffer system is the carbonate buffer system shown below. Calculate what happens to the [H,co,]/[HCO, ] ratio when the pHi esulting decreases from 7.40 to 7.35. H,CO3(aq) + H20(1): HC03-(aq) + H30'(aq) Kai = 43 x 10-7 5. Phosphate ions are abundant in cells, both as the ions themselves and as important sub- stituents on organic molecules. Most importantly, the pK, for the H2PO, ion is 7.20, which is very close to the normal pH in the body. H,P04-(aq) + H20(1) HP042-(aq) + H,0"(aq) a. What should the ratio [HPO,2]/[H,P0,] be to control the pH at 7.4? b. A typical total phosphate concentration in a cell, [HPO, ] [H2PO,], is 2.0 x 10-2 M. what are the concentrations of HP042-and H2 PO, at pH 7.4? 142
Jarrod RobelLv2
20 Apr 2019