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Provide answers to the following reaction
(a) The Knoevenagel reaction is a variation on the aldol condensation in which the nucleophile is the enolate anion of diethymalonate, the electrophile an aldehyde or ketone and The initial product i mechanism for the reaction where benzaldehyde is the aldehyde component and piperidine is the amine base. CO2Et CO2Et 15 Marks (b) How is it that a relatively weak base can be employed in the Knoevenagel reaction whereas a strong base such as sodium ethoxide is required to deprotonate an ester such as ethyl acetate? 2 Marksl (c) If the initial product of the Knoevenagel reaction is heated with acid, it is converted into an α,β-unsaturated carboxylic acid, PhCH-CHC01. Write a mechanism for this transformation 15 Marksl
Provide answers to the following reaction
(a) The Knoevenagel reaction is a variation on the aldol condensation in which the nucleophile is the enolate anion of diethymalonate, the electrophile an aldehyde or ketone and The initial product i mechanism for the reaction where benzaldehyde is the aldehyde component and piperidine is the amine base. CO2Et CO2Et 15 Marks (b) How is it that a relatively weak base can be employed in the Knoevenagel reaction whereas a strong base such as sodium ethoxide is required to deprotonate an ester such as ethyl acetate? 2 Marksl (c) If the initial product of the Knoevenagel reaction is heated with acid, it is converted into an α,β-unsaturated carboxylic acid, PhCH-CHC01. Write a mechanism for this transformation 15 Marksl
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Keith LeannonLv2
16 Feb 2019
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