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The reaction proceeds via the benzylic bromination at C-6 of folic acid followed by elimination of HBr to give a Schiff-base intermediate, which rapidly undergoes hydrolysis under the acidic reaction conditions to afford the aldehyde 8. What would the mechanism for this reaction look like?
O CO2hH HN folic acid 40% HBr, Br2 100 °C, 2 h 52% NCHO HN 8
The reaction proceeds via the benzylic bromination at C-6 of folic acid followed by elimination of HBr to give a Schiff-base intermediate, which rapidly undergoes hydrolysis under the acidic reaction conditions to afford the aldehyde 8. What would the mechanism for this reaction look like?
O CO2hH HN folic acid 40% HBr, Br2 100 °C, 2 h 52% NCHO HN 8
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Bunny GreenfelderLv2
26 Jun 2019
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