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11 Nov 2019
need a product separation scheme and product separation discussion discussion.
the format of the product separation scheme should be like this
EXPERIMENT 11 FRIEDEL-CRAFTS ACYLATION Introduction In this experiment you will study the reactivity and synthesis of substituted benzene rings. Aromatic systems may be substituted by reaction with an electrophile. The nucleophilic aromatic ring attacks the electrophile, adding the electrophile to the ring, and a stable aromatic system is reformed (Figure 1). Reactions like the Friedel-Crafts acylation fall under this general category of an Electrophilic Aromatic Substitution (EAS). EAS reactions like the Friedel-Crafts acylation involve the generation of an electrophile, E, first and then the reaction proceeds with a two-step addition/elimination process. A carbocation intermediate is formed when the nucleophilic Ï electrons of the aromatic ring attack the electrophile reagent, E. This carbocation intermediate, which is resonance stabilized, then reforms the aromatic system in the elimination step, with the loss of a proton, H. The overall EAS reaction, after the formation of the electrophile, E', is shown in Figure 1. Figure 1: Electrophilic Aromatic Substitution Mechanism (formation of E' not shown) Nucleophilic attack Carbocation Resonance + AH UNIVERSITYATALBANY State University of New York
need a product separation scheme and product separation discussion discussion.
the format of the product separation scheme should be like this
EXPERIMENT 11 FRIEDEL-CRAFTS ACYLATION Introduction In this experiment you will study the reactivity and synthesis of substituted benzene rings. Aromatic systems may be substituted by reaction with an electrophile. The nucleophilic aromatic ring attacks the electrophile, adding the electrophile to the ring, and a stable aromatic system is reformed (Figure 1). Reactions like the Friedel-Crafts acylation fall under this general category of an Electrophilic Aromatic Substitution (EAS). EAS reactions like the Friedel-Crafts acylation involve the generation of an electrophile, E, first and then the reaction proceeds with a two-step addition/elimination process. A carbocation intermediate is formed when the nucleophilic Ï electrons of the aromatic ring attack the electrophile reagent, E. This carbocation intermediate, which is resonance stabilized, then reforms the aromatic system in the elimination step, with the loss of a proton, H. The overall EAS reaction, after the formation of the electrophile, E', is shown in Figure 1. Figure 1: Electrophilic Aromatic Substitution Mechanism (formation of E' not shown) Nucleophilic attack Carbocation Resonance + AH UNIVERSITYATALBANY State University of New York
Hubert KochLv2
21 Jul 2019