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11 Nov 2019
GRIGNARD SYNTHESIS OF TRIPHENYLMETHANOL Certain alcohols can be synthesized from organic halides and esters: RX Mg > RMgX (a Grignard reagent) In our example, R = R' = phenyl, R.-methyl and X = Br When preparing and using Grignard reagents, anhydrous conditions must be maintained, it is difficult to start the reaction between magnesium and an organic halide in the presence of water. In addition, RMgX react with water to give RHHOMgX, so water could destroy the reagent before it has a chance to react with the ester Grignard reagents also react with aldehydes, ketones or epoxides to yield alcohols; these syntheses are covered in class. Please include a diagram of the apparatus, the equations for the reactions to be carried out and the following table of "Properties of Substances Involved in Experiment In the equations, don't use the symbols R, R', R" and X, but show the exact structures that these stand for Substance Density Weight in Number Volume Melting of Moles Wt. In g/mL in mlL in Magnesium Bromobenzene Methyl benzoate** Triphenylmethano (expecte expected) Probably listed as benzene, bromo- Probably listed as benzoic acid, methyl ester aOpen With Print
GRIGNARD SYNTHESIS OF TRIPHENYLMETHANOL Certain alcohols can be synthesized from organic halides and esters: RX Mg > RMgX (a Grignard reagent) In our example, R = R' = phenyl, R.-methyl and X = Br When preparing and using Grignard reagents, anhydrous conditions must be maintained, it is difficult to start the reaction between magnesium and an organic halide in the presence of water. In addition, RMgX react with water to give RHHOMgX, so water could destroy the reagent before it has a chance to react with the ester Grignard reagents also react with aldehydes, ketones or epoxides to yield alcohols; these syntheses are covered in class. Please include a diagram of the apparatus, the equations for the reactions to be carried out and the following table of "Properties of Substances Involved in Experiment In the equations, don't use the symbols R, R', R" and X, but show the exact structures that these stand for Substance Density Weight in Number Volume Melting of Moles Wt. In g/mL in mlL in Magnesium Bromobenzene Methyl benzoate** Triphenylmethano (expecte expected) Probably listed as benzene, bromo- Probably listed as benzoic acid, methyl ester aOpen With Print
Deanna HettingerLv2
20 Apr 2019