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11 Nov 2019
Ochem 2: Q: How to do prelab question #2 for experiment 4: applying the scientific method to the nitration of methyl benzoate
I tHIS CPude product in a small vial for HPLC analysis. Recrystallize the remainder of the product by placing the rest of the product in a reaction tube (or small test tube) and adding about an equal volume of methanol to the volume of product. Warm the mixture until the solid has completely dissolved. You might have to add a couple of drops of methanol from a Pasteur pipette to completely dissolve the solid. Slowly cool this mixture to 0 °C to crystallize the final product. If no solid is formed, you may need to evaporate some of the methanol or add water to the methanol solution; consult your instructor before proceeding. Filter the recrystallized product by vacuurm filtration on a clean Hirsch funnel. Allow the product to dry until the next laboratory period so that the melting point, HPLC, and IR analysis can be done. Pre-Lab Questions Include a data table in your pre-lab that includes the following compounds and information: methyl benzoate - molecular weight, density, boiling point, hazards; sulfuric acid - hazards; nitric acid - hazards. (1) Propose a hypothesis regarding what you believe will be the product of the mono- nitration of methyl benzoate. Qualitatively explain the basis of your answer using a discussion of the energies of reaction intermediates and the influence of the substituent on the electron density distribution of the arene ring. (2) Provide a mechanism for the formation of your proposed product including the structures (and resonance structures) of all intermediates and all electron-pushing Post-Lab Calculations and Questions (1) Compare the HPLC chromatogram for your crude product with that of methyl2-
Ochem 2:
Q: How to do prelab question #2 for experiment 4: applying the scientific method to the nitration of methyl benzoate
I tHIS CPude product in a small vial for HPLC analysis. Recrystallize the remainder of the product by placing the rest of the product in a reaction tube (or small test tube) and adding about an equal volume of methanol to the volume of product. Warm the mixture until the solid has completely dissolved. You might have to add a couple of drops of methanol from a Pasteur pipette to completely dissolve the solid. Slowly cool this mixture to 0 °C to crystallize the final product. If no solid is formed, you may need to evaporate some of the methanol or add water to the methanol solution; consult your instructor before proceeding. Filter the recrystallized product by vacuurm filtration on a clean Hirsch funnel. Allow the product to dry until the next laboratory period so that the melting point, HPLC, and IR analysis can be done. Pre-Lab Questions Include a data table in your pre-lab that includes the following compounds and information: methyl benzoate - molecular weight, density, boiling point, hazards; sulfuric acid - hazards; nitric acid - hazards. (1) Propose a hypothesis regarding what you believe will be the product of the mono- nitration of methyl benzoate. Qualitatively explain the basis of your answer using a discussion of the energies of reaction intermediates and the influence of the substituent on the electron density distribution of the arene ring. (2) Provide a mechanism for the formation of your proposed product including the structures (and resonance structures) of all intermediates and all electron-pushing Post-Lab Calculations and Questions (1) Compare the HPLC chromatogram for your crude product with that of methyl2-
Keith LeannonLv2
10 Apr 2019