pplease check in the correct boxes that correlated to the answer.
that serve to covalently conjugate a water-soluble molecule to a hydrophobic drug to prod compound. This the bloodstream and be filtered by the kidneys. There are five principal types o conjugatio acetylations; g Phase II drug metabolism reactions are catalyzed by a variety of enzymes uce a ne new compound will generally be sufficiently water-soluble to permit it to enter f covalent n reactions in phase II metabolism (in no particular order): glutathione conjugations; lycine conjugations; glucuronide conjugations; and sulfate conjugations. Each of conjugation reaction occurs on a specific type of functional group on the hydrophobic drug. again, in no particular order): aromatic acids; aromatic alcohols (phenols); amines (either Four of the conjugation reactions occur only with the following specific functional groups atic or alkyl); and organic halides. One of the conjugation reactions occurs with either acids, alcohols, or amines. The concentration of each type of covalent conjugate that is eventually excreted in the urine varies from that of the highest (#1) to that of the lowest (#5) Use the following clues and/or the information in your reading assignment to match the type of phase II conjugation reaction with the type(s) of functional group(s) that is/are involved nd the relative concentration of each type of covalent conjugate that is found in the urine. Then answer the questions on Blackboard for On-Line Quiz #22 Clue #1-The sulfate conjugation reaction does not occur with amine Clue #2-The products of the conjugation reaction that occurs with organic halides (which reaction is neither the sulfate conjugation nor the acetylation) are found in a lower concentration in the urine than are the products of the conjugation reaction that occurs with either acids, alcohols, or amines (which is either glucuronide conjugation or glutathione conjugation). However, the products of the conjugation reaction that occurs with organic halides are found at the next highest concentration in the urine above that of the products of the conjugation reaction that occurs with aromatic alcohols. Clue #3-The products of the acetylation reaction are the fifth highest (#5) in the urine; the products of the glutathione conjugation are not the highest (#1) in the urine Clue #4-Either the glucuronide conjugation or the glycine conjugation reacts exclusively with aromatic acids
