For the last question, is it correct that approach A would be the right one for scenario 1 since it needs more Grignard reagents and thus, more efficient to use the commercially available Grignard reagent? And approach B for scenario 2.
5. Perhaps surprisingly, the transformation below can be accomplished without the need for protecting groups. To be successful, however, a large excess of the Grignard reagent (BrMgR) must be employe d. ROH A. (01y2] What is the minimum number of equivalents of the 1. BrMgR, THF Grigmard reagent needed to produce 1 equivalent of the product above? Justify your answer by explaining why each equivalent of the Grignard reagent is needed OH)- OH 2. H30 â w.thom tie st of pnttchy grtars, 4 et.. of cngend reorntÇ, drdrette B. Alternatively, propose a reaction sequence to make the product utilizing a protecting group strategy to produce the quantity of the Grignard reagent needed. BAF H,0 ì nf oTMg 01m ou ì consider A./f/301 Let's wrap this problem up by comparing the different approaches above (A and B) ake the product where the different Grignard reagents below are used Decide which proach (A or B) would-be preferable for each Grignard and justify your answer. rignard reagent to be used is readily available commercially and relatively inexpensive. nrwengend nr.grns Mr, dtt^^ã Scenario 2: in this case, the Grignard reagent was generated from a previously synthesized alkyl bromide (itself requiring five costly reactions to prepare in low yield) syethrs ,ing .
