How to create a table of reagents with the information given. Ester of choice is isoamyl acetate
7. SYNTHISIS OF FRUITY ESTERS USING THE FISCHER ESTERIFICATION REACTION H2504 (cat) soamyl alel acetic acie H-S04 (cat) n-butanolaccid H2504 (cat) the chemistry of fragrances, chemical equilibria Experimental techniqees: Microscale reflux, NMR, microscale aqueous extraction Adapted from: Palleros, P. K etal "Microscale Organic Laboratory". p. 480. Befone he lab period pick one of the esters drawn ahove. If you work in a team, try to coordinate this with your teammate befosehand. If you don't do this in time for the lab, then just worry about it when you get to lab, and then copy(and double-check) the rclevant dataãquestions 3a and 3b) for the ester you decide to make with your partner 2. Prepare your pre-experiment notcbook entry (lowchart, table of reagents with physical constamts, etc) 3. Answer the following questions: For only the ester you are making, please draw a dctailed clectron-pushing mechanism to show the formation of compound. There are many sesources available to you on the web, etc) fr the mechamism of the Fischer esterification reaction a. b. You will start with 500 mg of one of your starting alcohel(whichever one you will be using to gencrate your product). While the acohols are liquids, we will measure them by mass directly on the balance, no by volume (ie. the density of the alcohol will not be used: pretend the alcohol is a solid). Acetic acid (or propionic acid) will be mcasured by volume. Delermine the volume of acetic acid (or propionic acid) to add that will correspond to 40 molar equivalents based on mmols of starting c. Considering that the reaction produces water in the mechanism (question a), what reagents could be added to the reaction mixture to enhance coeversion to product? (Think of a specific Reaction Inlo 10 ml RBF, add the aleohol you chose (500 mg), acetie acid or peopionie acid (alulated quantity, by pluringe, and cone, sulfuric acid (3äº ops, no more). Do not spill conc, sulfuric acid on yourself! 2. Altach (screw on) a microscale condenser (with rubber O-ring seall) to the RBF, and flow water through You can the bottom of the condenser. Be very careful when tuming the water on to avoid a waler spill then directly clamp the condenser and have the RBF suspended it into the sand bath Heat the reaction mixture in a sand bath to a gentle boil (roughly-130-140â, but it varies for each experiment) for 45 min, and them allow the mixture to cool to necarly ambient temperature 3. Workup and purification Transfer the reaction mixture by pipette from the RBF to a 4 ml conical vial 5. Rinse the residual reaction misture from the RBF to the cotical vial using 2 ml 5% NaHCO/19% NaCl 6. Cap the tube and invert it several times to mix the layers. Vent the tube as necessary, Allow the layers 7. Wash the product with additional 5% NaHCO,19% NaCI
