Question

Consider the dimerization 2A to A2, with forward rate constant kaand backward rate constant kb. (a) derive the following expressionfor the relaxation time in terms of the total concentration ofprotein [A]tot = [A] + 2[A2]: (1/tau^2) = kb^2 + 8kakb[A]tot
(b) describe the computational procedures that lead to thedetermination of the rate constants ka and kb from measurements oftau for different values of [A]tot
(c) use the data provided below and the procedure you outlined inpart b to calculate the rate constants ka and kb, and theequilibrium constant K for formation of hydrogen-bonded dimers of2-pyridone:

[A]tot 0.500 0.352 0.251 0.151 0.101
tau 2.3 2.7 3.3 4.0 5.3