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23 Nov 2019
The absorption of drug molecules such as aspirin(acetylsalicylic acid) depends on
their ability to penetrate nonpolar cell membranes. A large KPvalue indicates that
the drug is able to do this efficiently. AH2O ? Amembrane
Kp= [A]membrane / [A]H2O
A. Aspirin has a carboxyl group with a pKa = 3.5 Calculate theexact percent of the drug
in the uncharged (neutral) form at pH = 2. Calculate exactly the KPvalue in the stomach
at pH = 2. Explain your reasoning and any simplifying assumptions.Show all work.
B. If the large intestine has a pH = 5.5, estimate the percentin the uncharged form at this
pH. What do you predict will be the ?G
The absorption of drug molecules such as aspirin(acetylsalicylic acid) depends on
their ability to penetrate nonpolar cell membranes. A large KPvalue indicates that
the drug is able to do this efficiently. AH2O ? Amembrane
Kp= [A]membrane / [A]H2O
A. Aspirin has a carboxyl group with a pKa = 3.5 Calculate theexact percent of the drug
in the uncharged (neutral) form at pH = 2. Calculate exactly the KPvalue in the stomach
at pH = 2. Explain your reasoning and any simplifying assumptions.Show all work.
B. If the large intestine has a pH = 5.5, estimate the percentin the uncharged form at this
pH. What do you predict will be the ?G
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