Question

Adipose tissues contain high levels of fructose. Fructose can enter the glycolytic pathway directly through the reaction

Fructose + ATP <-->Fructose-6-phosphate + ADP

(a) Calculate the standard Gibbs energy change (G’) for this reaction.

(b) If fructose is substituted for glucose in “glycolysis,” what would the overall reaction be for the conversion of fructose to glyceraldehyde-3-P, Part 1 of glycolysis? Calculate G’ and G. Assume that the concentration of fructose is 5.0 mM.

(c) What would the overall reaction be for the complete metabolic cycle (Part 1 + Part 2). Calculate G’ and G.