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The amino acid methionine is formed by a methylation reaction of homocysteine with N-methyltetrahydrofolate. The stereochemistry of the reaction has been probed by carrying out the transformation using a donor with a âchiral methyl groupâ in which deuterium (D) and tritium (T) isotopes of hydrogen are present. Does the methylation reaction occur with inversion or retention of configuration? What mechanistic inferences can you draw?
The amino acid methionine is formed by a methylation reaction of homocysteine with N-methyltetrahydrofolate. The stereochemistry of the reaction has been probed by carrying out the transformation using a donor with a âchiral methyl groupâ in which deuterium (D) and tritium (T) isotopes of hydrogen are present. Does the methylation reaction occur with inversion or retention of configuration? What mechanistic inferences can you draw?
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