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11 Dec 2019

When glucose enters a cell, it is converted quickly to glucose-6-phosphate. Why is this chemical modification of glucose significant to the cell?

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Reid Wolff
Reid WolffLv2
13 Dec 2019

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Related questions

Please select ALL that apply.

The radioactively labeled compound [18F]fluorodeoxyglucose (FDG) is used to measure glucose uptake in cells. FDG, a derivative of glucose in which the C2 hydroxyl is replaced with fluorine, is phosphorylated to FDG-6-phosphate upon entering the cell but cannot proceed any further through glycolysis. The phosphorylated FDG remains in the cell, and its presence can be detected and quantitated, providing information on the rate of glucose uptake. (Cancer cells take up glucose particularly rapidly.)

a. Draw the structure of FDG.

b. Why does phosphorylation trap the FDG in the cell?

c. Why is FDG unable to proceed through glycolysis past the hexokinase reaction? (Hint: When glucose-6-phosphate is converted to fructose-6-phosphate, the ring opens, the isomerization reaction takes place, and then the ring closes again.)

d. Is FDG taken up only by cancer cells?

UESTION 8

What type of chemical reaction occurs when glucose-6-phosphate is converted to fructose-6-phosphate? You may need to use your textbook to look up the chemical structures of the compounds.

Group Transfer

Isomerization

Ligation

Oxidation-Reduction

Addition/Removal

Hydrolysis

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