The following questions are related to glucose and its transport into cells.
A. Why do cells need a protein to transport glucose across the cell membrane? i.e.could glucose simply diffuse across the lipid bilayer? (1 point)
B. Even after glucose is transported into the cell, there is effectively no increase in intracellular glucose concentration. This can be attributed to the action of hexokinase, the first enzyme in the glycolytic pathway. Explain. (2 points)
C. GLUT1 is a glucose transporter found in many cells. It facilitates the movement of glucose down its concentration gradient. GLUT1 has a lower KM for glucose (~1 mM) than its family member GLUT2 (~15mM). Except during starvation, the brain uses glucose as its sole metabolic fuel and consumes ~40% of the glucose circulating in the body. Which of the two, GLUT1 or GLUT2, would you expect to find in brain tissue? Explain. (2 points)
The following questions are related to glucose and its transport into cells.
A. Why do cells need a protein to transport glucose across the cell membrane? i.e.could glucose simply diffuse across the lipid bilayer? (1 point)
B. Even after glucose is transported into the cell, there is effectively no increase in intracellular glucose concentration. This can be attributed to the action of hexokinase, the first enzyme in the glycolytic pathway. Explain. (2 points)
C. GLUT1 is a glucose transporter found in many cells. It facilitates the movement of glucose down its concentration gradient. GLUT1 has a lower KM for glucose (~1 mM) than its family member GLUT2 (~15mM). Except during starvation, the brain uses glucose as its sole metabolic fuel and consumes ~40% of the glucose circulating in the body. Which of the two, GLUT1 or GLUT2, would you expect to find in brain tissue? Explain. (2 points)
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