Glycogen phosphorylase catalyzes the removal of glucose 1-phosphate from glycogen: Glycogenn + Pi â Glycogenn-1 + glucose 1-phosphate ÎG°â = +3.1 kJ/mol
a) Comment upon the standard free energy for this reaction.
b) Using the value of ÎG°â, calculate the value of the equilibrium constant for this reaction (hint: removal of a glucose unit from glycogen does not change the concentration of glycogen).
c) Using the value of K, calculate the equilibrium ratio of [Pi] to [glucose 1-phosphate].
d) The observed physiological ratio of [Pi] to [glucose 1-phosphate] is 100:1. Under these conditions, calculate ÎG under physiological conditions.
e) Comment on the difference between the equilibrium and physiological ratios, assuming that all of the glucose 1- phosphate formed eventually enters the glycolysis pathway.
Glycogen phosphorylase catalyzes the removal of glucose 1-phosphate from glycogen: Glycogenn + Pi â Glycogenn-1 + glucose 1-phosphate ÎG°â = +3.1 kJ/mol
a) Comment upon the standard free energy for this reaction.
b) Using the value of ÎG°â, calculate the value of the equilibrium constant for this reaction (hint: removal of a glucose unit from glycogen does not change the concentration of glycogen).
c) Using the value of K, calculate the equilibrium ratio of [Pi] to [glucose 1-phosphate].
d) The observed physiological ratio of [Pi] to [glucose 1-phosphate] is 100:1. Under these conditions, calculate ÎG under physiological conditions.
e) Comment on the difference between the equilibrium and physiological ratios, assuming that all of the glucose 1- phosphate formed eventually enters the glycolysis pathway.
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