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Aspirin has the structural formula

At body temperature (37 °C), Ka for aspirin equals 3 × 10-5. If two aspirin tablets, each having a mass of 325 mg, are dissolved in a full stomach whose volume is 1 L and whose pH is 2, what percent of the aspirin is in the form of neutral molecules?

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Patrina Schowalter
Patrina SchowalterLv2
25 May 2020

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Related questions

Aspirin ​Aspirin (Figure P15.63) is an acid substance whose pKa = 3.50 at body temperature

(37°C). One standard adult aspirin contains 325 mg of the drug. If you take 1 aspirin on a full

stomach (assume a volume of 1 L and a pH of 2.0), what percent of the aspirin in your stomach

is present as the anion?


The absorption of drug molecules such as aspirin (acetylsalicylic acid) depends on their ability to penetrate nonpolar cell membranes. A large KP value indicates that the drug is able to do this efficiently. AH2O ❝ Amembrane [A]membrane KP = ❯❯❯❯ [A]H2O A. Aspirin has a carboxyl group with a pKa = 3.5 Calculate the exact percent of the drug in the uncharged (neutral) form at pH = 2. Calculate exactly the KP value in the stomach at pH = 2. Explain your reasoning and any simplifying assumptions. Show all work. B. If the large intestine has a pH = 5.5, estimate the percent in the uncharged form at this pH. What do you predict will be the ΝG°transfer into the membrane? Explain your reasoning and any assumptions and show all work. C. Do you expect aspirin to cross the cell membrane more efficiently in the stomach or in the intestine? Quantify how much better. Explain your reasoning and any assumptions.

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