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Following is a retrosynthetic analysis for ibutilide, a drug used to treat cardiac arrhythmia. In this scheme, Hept is an abbreviation for the 1-heptyl group.

(a) Propose a synthesis for ibutilide starting with aniline, methanesulfonyl chloride, succinic anhydride, and N-ethyl-1-heptanamine.

(b) Is isobutilide chiral? If so, which of the possible stereoisomers are formed in this synthesis?

 

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Amarildo Kociaj
Amarildo KociajLv10
9 Jan 2021

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