I just need help with the last question:
The fitnesses of sickle-cell anemia genotypes in the presence of malaria have been calculated as follows:
wAA = 0.9 (Homozygous for HbA allele)
wAS = 1 (Heterozygous carrier)
wSS = 0.2 (Homozygous for HbS allele)
What is the selection coefficient (s) against the normal allele? Answer: 0.10
Given the data above, what is the selection coefficient (t) against the sickle-cell allele? Answer: 0.8
Based on your answers above, what is the predicted equilibrium frequency (q) of the sickle-cell allele in the presence of malaria? Answer: 0.11
Based on your answers above, how many cases of sickle-cell anemia would you expect to see per 10,000 individuals in an African population subject to malaria? (Hint: use Hardy-Weinberg expectations to go from allele frequency to genotype frequency.)
I just need help with the last question:
The fitnesses of sickle-cell anemia genotypes in the presence of malaria have been calculated as follows:
wAA = 0.9 (Homozygous for HbA allele)
wAS = 1 (Heterozygous carrier)
wSS = 0.2 (Homozygous for HbS allele)
What is the selection coefficient (s) against the normal allele? Answer: 0.10
Given the data above, what is the selection coefficient (t) against the sickle-cell allele? Answer: 0.8
Based on your answers above, what is the predicted equilibrium frequency (q) of the sickle-cell allele in the presence of malaria? Answer: 0.11
Based on your answers above, how many cases of sickle-cell anemia would you expect to see per 10,000 individuals in an African population subject to malaria? (Hint: use Hardy-Weinberg expectations to go from allele frequency to genotype frequency.)
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