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23 Nov 2019

hematology help-----------

Which of the following tests best determines the adequacy of production of RBC's in the bone marrow?

a. Retic count
b.

RDW
c.

Erythrocyte sedimentation rate (ESR)
d.

Hematocrit

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Trinidad Tremblay
Trinidad TremblayLv2
24 Aug 2019
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Related questions

QUESTIONS TO ANSWER:
1.Looking at Jane’s lab profile, it is indicative of what condition?
2.What are the two most common causes of this condition?
3.Which lab result is critical in the diagnosis of this disease?
4.Discuss the significance of the Hematology results?

Jane L) a 30-year-old woman, was seen in the ER with severe epigastric pain radiating to the back that woke her from sleep. She also complained of nausea and vomiting. The chemistry and hematology tests shown in Tables 2—8 and 2—9 were ordered.

Jane L. Reference Range

Sodi um

140

135-145 mEq/L

Potassium

3.6

3.6—5.0 mEq/L

Chloride

106

98-107 mEq/L

C02

29.0

24.0-34.0 mEq/L

Glucose

116

80-120 mg/dl,

Bilirubin, total

0.2

0.2—1.9 mg/dL

AST

ALP

Protein

26

53

6.8

5-40 IU/L

30-157 IU/L

6.0-8.4 gidL

2120

2121

Reference Range

BUN

13

7—24 mg/dL

Creatinine

1.2

1.2

0.5—1.2 mg/dL

Calcium

9.0

8.8

8.5—10.5 mg/dL

Albumin

4.2

3.5-5.0 g/dL

ALT

23

NT

5—40 IU/L

Amylase

738

265

10-110 IU/L

Lipase

3970*

320

31-186 IU/L

335

NT

13-86 IU/L

Cholesterol

NT

165

Recommended (desirable): < 200 mg/dL

Triglyceride

NT

155

Recommended (desirable): < 250 mg/dL

2120

2121

Reference Range

WBC

RBC

ESR

12.1

4.93

40

10.8

4.76

5-10 x 109/1.

4.0-5.0 x

0—20 mm/h

HDL 35 Recommended (desirable): 60 mg/dL LDL NT 99 Recommended (desirable): 130 mg/dL *Lipemic sample, results rechecked.

Abbreviations: ALT, alanine aminotransferase; ]GT, gamma glutamyltransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NT, not tested.

Table 2-9 " HEMATOLOGY

Abbreviations.' ESR, erythrocyte sedimentation rate; NT, not tested.


Background

A 10-month-old Central American child was referred to the laboratory for testing after being seen by a pediatrician. The phlebotomist noted that the child was very pale and listless. The following tests were ordered: CBC with platelet, reticulocyte count, total serum bilirubin, total serum iron, and total iron-binding capacity (TIBC), as well as a stool examination for occult blood, ova, and parasites. The results are listed below:

Parameter

Result

Reference Range

Hemoglobin

5.6 g/dL

10.5-13.5 g/dL

Hematocrit

24%

33-42%

RBC

3.5 x 1012/L

3.7-5.3 x 1012/L

WBC

10.5 x 109/L

6.0-18.0 x 109/L

Platelet

200 x 109/L

150-450 x 109/L

MCV

68.6 fL

74-91 fL

MCH

16 pg

23-31 pg

MCHC

23%

32-36%

Retic count

0.5%

0.5-2.0%

Total serum bilirubin

0.9 mg/dL

0.3-1.9 mg/dL

Serum iron

40 µg/dL

50-160 µg/dL

Serum ferritin

5 ng/mL

15-400 ng/mL

TIBC

465 µg/dL

250-400 µg/dL

% Saturation

8.6%

20-55%

The stool examination was negative for occult blood, ova, and parasites.

What kind of erythrocyte morphology would you expect to observe in the peripheral blood of this patient?

What would the bone marrow look like in this patient if we stained a slide with Wright’s Stain? And with Prussian blue?

Which of the following statements is NOT CORRECT about the hematopoietic niche in the bone marrow? Select one: a. The bone marrow is functional in all the bones of the body early in gestation. b. CXCL12/SDF-1 is a chemokine responsible for homing of blood stem cells to the bone marrow. c. Mobilized (short term) HSCs down-regulate the expression of Angiopoietic-1 d. The osteoblast are the progenitors of the osteoclasts.

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