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BIOB10H3 Lecture Notes - Peroxisomal Targeting Signal, Listeria Monocytogenes, Phagocytosis

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School
UTSC
Department
Biological Sciences
Course
BIOB10H3
Professor
Tanya Da Sylva

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Document Summary

Cellular uptake of particles and macromolecules: two separate categories: Phagocytosis: cell eating : uptake of relatively large particulate matter. (>0. 5 mm in diameter: for food, eg. unicellular heterotrophic protists, for protection, eg. , macrophage, neutrophil immune cells, en trapment (pseudopods) -> engulfment -> digestion -> Macrophage receptors on cell binds particle (bacteria, dead cells, etc. ) Macrophages have fc-receptors that binds to antibodies (igg) coating ( opsonize") pathogens. Phagocytosis by macrophages is induced in both innate(fast and first) and adaptive (antibody) immunity. Modes of bacteria escaping the lysosomes/phagosome: escape: listeria monocytogenes www. notesolution. com, prevent fusion with lysosomes: mycobacterium tuberculosis, survive in phagolysosome: coxiella burnetii. Uptake of proteins into peroxisomes: peroxisomes have only two compartments in which proteins can be placed. Internal matrix: proteins bound for peroxisome have peroxisomal targeting signal (pts, receptors bind to proteins in the cytosol and shuttle them to surface where receptor and ligand travel through peroxisome membrane to peroxisomematrix. Uptake of proteins into chloroplasts: 6 compartments.

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