CSB327H1 Lecture Notes - Lecture 17: Glycation, Methylglyoxal, Hyperglycemia
28 Dec 2012
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Document Summary
Heart failure: functionally insufficient pumping capacity of blood to meet metabolic needs of tissue, underlying mechanism. Diabetic cardiomyopathy diabetes mellitus diastolic abnormalities decrease in left ventricular ejection heart failure: diabetic cardiomyopathy is accelerated by diabetes and hyperglycemia. Cardiomyocyte function is intimately tied to the interstitial collagen i matrix: collagen fibrils are properly oriented to promote efficient contractions, cardiac hypertrophy and dysfunction, in association with fibrosis, is a common complication in diabetes. Ecm components of the myocardium: 25% cardiac myocytes. Lv muscle sheet layers endomysium cardiac myocytes + collagen + capillaries: 40% cardiac fibroblasts. Diabetes hyperglycemia glycation: diabetes is a chronic disease in which there are high levels of sugar in the blood. Lack of insulin due to loss of beta cells in the pancreas (type i, juvenile onset) Target cells are insensitive to insulin (type ii, adult onset) Insulin resistant: hyperglycemia is high blood sugar. Lead to degradation of glucose that results in the formation of highly reactive sugar intermediates.
