CSB327H1 Lecture Notes - Lecture 5: Basal Lamina, Mesenchymal Stem Cell, Type I Collagen
5 Jan 2013
School
Department
Course
Professor
Document Summary
Csb327 lecture 5 notes basal lamina and embryogenesis (september 24, 2012) 1 lecture topics: we talked about getting out of the cell. We used type i collagen as a prototype. We followed the fate of an alpha chain as it assembles into a triple helix to the formation of fibers. We looked at pathologies that were associated with events that occurred in the er. For example, the lack of hydroxylation translated into the lack of stability of the triple helix. Even though a mutation might occur and interfere with an event in the er, such as the formation of a stable trimer, it can be translated into abnormal fibrils outside as a downstream effect. We looked at the basal lamina because the basal lamina (specialized extracellular matrix sheet) communicates with interstitial matrices. I want to talk about different types of states of cells and how powerful the ecm is in the absence of growth factors.
