EESA10H3 Lecture : Week 10 Lecture

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Toxicology: assessing chemical hazards (1: how harmful a substance is depends on: Antagonistic = when one chemical reduces the toxicity of another one www. notesolution. com: some vitamins (a and e) may reduce human reaction to some carcinogens. Synergistic = when two chemicals are together, one of them become more toxic: e. g. smoking in the presence of asbestos, multiple chemicals food additives, pesticides, air pollution, receptor, dose, response. Acute dose refers to single dose, usually high. Chronic dose repeated or continuous low dose over time. Long term low dose over a life time. Toxicology: response: response, nonspecific affects the whole body system. Burning destruction of cells caused by exposure to high concentration of strong acids or bases. Narcosis depression in sensory activity, reversible, caused by alcohols, ethers, benzene: specific. Carcinogenesis: acute toxicity rapid death (usually acute dose causes acute toxicity, chronic toxicity related to chronic dose e. g. cases of cancer.

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