BIOLOGY 2D03 Lecture Notes - Arachidonic Acid, Adipocyte, Cyclic Adenosine Monophosphate
28 Jan 2013
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Acc: makes malonyl coa biotin carboxylase: adds co2 to biotin; uses atp transcarboxylase: transfers c02 to acetyl coa. Acyl transfer acetyl coa to condensing enzyme (ce) malonyl coa to acyl carrier protein (acp) Reduction reduce ketone to alcohol (oxidize nadph) dehydrate reduce double bond (oxidize nadph) Transfer new chain from acp to ce after 16 carbons, palmityl thioesterase frees from complex. Origin of cytosolic acetyl-coa: pyruvate from glycolysis enters mitochondria, converted to acetyl coa acetyl coa condenses with oaa to make citrate citrate exported from liver mitochondria b/c icdh inhibited no tca! Citrate lyase: citrate oaa + acetyl coa. Malate reduced, decarbed to pyruvate in cytosol nadph produced. Acc acetyl coa activates (feed-forward) citrate activates (feed-forward) fatty acids inactivate (feedback) phosphorylation by ampk, campk in times of low energy. Insulin favors fa synth activates: citrate lyase txn. B-oxidation high nadh oaa reduction to malate gluconeogen. as consequence, not enough oaa for citrate synthase no citrate.
