BIOLOGY 2C03 Lecture Notes - Granule Cell, Purkinje Cell, Dentate Nucleus
28 Jan 2013
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Document Summary
Contains all basic info from lab 10 cerebellum as well: introduction. Basic circuit is a loop between cerebral cortex, basal ganglia/cerebellum, and thalamus, with modulating input at second item. Anterior, posterior, flocculonodular lobes ; primary and posterolateral fissures. Input: vestibular nuclei and scarpa"s (vestibular) ganglion. Output: vestibular nuclei to control head/eye movements (eg vor) Clinical signs: impaired vestibular function, poor eye control, nystagmus. Vermis fastigial nucleus, paravermis interposed nuclei. Clarke"s nucleus (via dorsal spinocerebellar tract) and lateral cuneate nucleus (via cuneocerebellar tract) provide ipsilateral muscle spindle. Vermis fastigial nucleus pontine reticular formation for extensor a. Paravermis interposed nuclei red nucleus, vl thalamus for motor function. Cerebellar hypotonia: reduced muscle tone due to reduced deep nuclei activity. Dysmetria: failure to make seamless coordination, muscle overshoots. Input: cerebral cortex via contralateral pontine nuclei. Output: dentate nucleus vl thal. for motor planning and medial thal. for working memory. Clinical signs: decomposition of movement into a series of individual acts separated by stops.
