5-350 Lecture Notes - Decapentaplegic, Spatial Planning, Tx Network

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See 5 pages of notes in binder on introduction to patterning : overview. Much of our knowledge of a/p and d/v axis development comes from. Proper spatial development is determined by differential gene expression. Different hox genes are expressed along the a/p axis, and this determines fate of cells in each segment. Interestingly, order of hox genes in genome is same order of expression. A/p axis is established when embryo is a syncytium. Bicoid mrna localized to anterior pole; nanos mrna localized to posterior pole to form mechanism) Bicoid and nanos protein form opposing gradients along a/p axis as cells begin. Hunchback txn is activated by bicoid and translation repressed by nanos; hence, Hunchback has a graded distribution along a/p axis. Kruppel, knirps, and giant genes are have different thresholds for repression by. Hunchback; hence hb sets the anterior boundary for their expression. (there is an anterior region that expresses giant, under a different control.

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