BIOL 2050U Lecture Notes - Lamprey, Vasodilation, Dendritic Cell
Document Summary
Innate immunity-prepared to mount a fast, stereotyped defense against attack (rapid, general) Adaptive immunuity-specific, learned, response to a specific attack (slower, specific) Need efficiency, and accuracy, (prevent self destruction), quick initiation, in dealing with pathogens. Sends activated immune cells to site, sequesters pathogens, limits damage, initiates repair. Due to inflammatory mediators effect on microvasculature at injury or infection site. Innate immune response- preexisting ability to recognize broad structural patterns as foreign. Cells (mac/neut/nkc) use germline encoded receptors to recognize patterns. Various weapons to kill general classes of pathogens. Release mediators to induce adaptive immune system learned ability after initial exposure to rec. precise molecular structures as. Cells (b/t) use receptors rearranged in devt to rec. specific antigens from specific. Activated ai cells respond to kill specific antigens. Clonal distribution- delay until the cell with the right receptor reaches site of infection.
