Class Notes for BIOL 2050U at UOIT

T CELL TOLERANCE Immune activation vs. tolerance is CIRCUMSTANCE driven Janeway: immune system responds to antigen + presence of PAMP/PRR int. no PAMP/PRR interaction  tolerance Matz...

T CELL TOLERANCE AND DEVELOPMENT TOLERANCE – unresponsiveness to a particular ag (usually self) self-tolerance is learned by developing immune system FREEMARTIN condition in twin catt...

TUMOR IMMUNOLOGY Coley’s Toxin – activation of T cells to fight tumors MOUSE STUDIES: RAG2 knockout mice  no B/T cells  totally immunodeficint  MORE cancer RAG/STAT double knockouts are even more...

T-CELL ANTIGEN RECOGNITION B and T cells are morphologically identical Claman studies – BOTH T and B cells are necessary for antibody response to antigen T cells obey CLONAL SELECTION also T cells don’t s...

NATURAL KILLER CELLS part of innate immunity; no prior exposure is necessary anti viral, anti-tumor, transplant rejection, materno-fetal interaction roles protection during T-cell priming period ...

Outline of Lecture 11 T Cell Selection and Central Tolerance I. Tolerance defined A) Freemartin cows indicate that self tolerance is learned by developing immune system B) Neonatal t...

LYMPHOCYTE ACTIVATION all immune system responses begin with NAÏVE T CELL ACTIVATION features of T-cell activation that are distinct from other receptor-ligand processes requires MHC-presentation small pro...

LYMPHOID ORGANS highly localized microenvironments are structural basis of immune response lymphocyte specificity is quite rare, as is their dispersement throughout the body soln: highly orchestrated movements of...

IMMUNOLOGY LYMPHOCYTE ACTIVATION all immune system responses begin with NAÏVE T CELL ACTIVATION features of T-cell activation that are distinct from other receptor-ligand processes requires MHC-presentation ...

Innate Immunity (Principles, Patterns, Receptor Signaling) L2/p.1 Innate Immunity-prepared to mount a fast, stereotyped defense against attack (rapid, general) Adaptive Immunuity-specific, learned, response to a s...

INTRO – immune system to protect from: microorganisms (parasites, fungi, bacteria, viruses) antigen recognition - antibodies (B-cells), T-cell receptors - ANY or...

INNATE IMMUNITY rapid (minutes/hours), generalized response to injury FEATURES: primary response shares effectors w/ adaptive immunity; stimulates adaptive immunity ...

Outline of Lecture 02 Immunoglobulins I, Structure and Function I. Innate vs. Adaptive Immunity A. Innate immunity: quick response to general invariant microbe features B. Adaptive immu...

IMMUNODEFICIENCY 150 known diseases 2 mechanisms of hypogammaglobulinemia  2 clinical manifestations 1) poor maturation of B cells: X-Linked Agammaglobulinemia prototypic antibody deficiency disease anti...

Outline of Lecture 04 Immunoglobulins III, B Cell Development I. Overview B Cell development has two phases (see Fig. 1, p. 59): - Antigen independent: (bone marrow), V(D)J a...

perm ach artsMT T rigger Points II: Extremities T rigger Points II: Extremities ...

p erm ac ha rts MT Trigger Points I: Head & Torso 2nd EDITION ...

p er m a ch a rts MT The Skin The Skin ...

pe rm a ch ar ts MT Spinal Cord 2nd EDITION Figure ...

This Guide is the progressive companion to the Cellular Biology title. The complexities of human physiology are made much clearer through the bright graphics and intelligently coordinated text boxes and glossaries that are...

pe rm a ch ar tsMT Muscular Attachments 2nd EDITION ...

Muscular System: pe rm ac ha rts MT Head & Torso 2nd EDITION ...

p er m a ch ar tsMT Muscular System: EExtremities 2nd E...

p e rm a ch a rts MT Nervous System 2nd EDITION Fi...

p erm a ch ar tsMT CCardiorespiratory System 2...

permacharts TM Cardiovascular Physiology 2nd EDITION HEART STRUCTURE & FUNCTION ...

p e rm ac h a rts MT Cellular Anatomy Cellular Anatomy ...

l e a r n • r e f e r e n c e • r e v i e w permacharts TM CCellular Biology BIOLOGY BASICS C...

The specific aspects of cellular respiration are explained in this helpful Guide. The fundamental processes such as the electron transport chain, proton pumps, ATP synthetase, and glycolysis are each described with helpful...

pe rm a ch a rtsMT DDigestive System 2nd EDITION Fi...

permacharts TM IImmunology 2nd EDITION G ENERAL INFORMATION - AN OVERVIEW ...

p erm ac hartsMT Brain 2nd EDITION FIGURE 1: GROSS ANATOMY (LATERAL VIEW) ...

p erm a ch ar tsMT CCirculatory System 2nd EDITION Figure...