BGEN 3020 Lecture Notes - Trace Metal, Hemoglobin, Vicia Faba

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

Warm reacting antibodies are igg and cold reacting is igm. Mc autoimmune hemolytic anemia = warm; mcc of it = lupus. When you have autoimmune dz in your family, you have certain hla types that predispose you to that autoimmune dz. Therefore, you should not be surprised if you have one autoimmune dz you"re likely to have another. So, pts with lupus commonly also have autoimmune hemolytic anemia, autoimmune thrombocytopenia, autoimmune neutropenia, and autoimmune lymphopenia. For example: the mcc of hypothyroidism = hashimoto"s thyroiditis; these pts commonly have other autoimmune dz"s ie pernicious anemia, vitiligo, autoimmune destruction of melanocytes). So, if you have one autoimmune dz, you are likely to have others (ie if you have a hemolytic prob, it is prob autoimmune related). Hla (ie if they have the hla type specific for lupus there are specific hla"s for diff dz"s). Therefore, hla is the best way to see if pt is predisposed to something.