MICR 3230 Lecture Notes - Pertussis, Cell-Mediated Immunity, Innate Immune System
28 Feb 2013
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Document Summary
Vertebrates have 2 types of immunity: innate and adaptive immunity. Lymphocytes and antigen-presenting cells cooperate in adaptive immunity. Collaboration bw innate and adaptive immunity increases immune response. T-cell receptors recognize only antigen combined w/ mhc molecules. Dysfunctions of the immune system incl: allergies, asthma, immunodeficiency, autoimmunity. Galt thymus spleen bone marrow lymph nodes germinal centers. Innate immunity constitutes a 1st line of defense, which includes barriers, phagocytic cells, and molecules that recognizes certain classes of pathogens. Steps involved in inflammation: 1) vasodilation 2) exudation via increased capillary permeability 3) phagocyte influx 4) tissue damage by chemical mediators. Has 4 characterisitics: 1) antigenic specificity 2) diversity 3) immunologic memory 4) Conclusion: selective theory ehrlich suggested that interaction bw an infectious agent was like the fit bw a lock and key. Interaction bw a ninfectious agent and a cell-bound receptor would induce the cell to produce and release more receptors w/ the same specificity.
