BIOC13H3 Lecture Notes - Lecture 23: Acetyl-Coa, Carnitine, Beta Oxidation
Document Summary
Skip a few slides and accept that fatty acids can get from the blood off of the albumin and get into the cytosol of the cell. In first step, the fatty acid will get activated, similar to glucose activation during glycogen synthesis. That creates a fatty acyl adenylate, it remains enzyme bound so the enzyme doesn"t release the intermediate. The energy to drive the synthesis of the thioester comes from the simultaneous breaking of the bond between amp and the fatty acid part of the molecule. Delta g for this process is near equilibrium, this confirms that the fatty acyl coa is energetically equivalent to that atp. Similar to glucose activation, where we turned glucose to udp glucose. This free energy released from the degradation of the pyrophosphate is what serves to drive the entire process towards the synthesis of fatty acyl coa. 2 fates for fatty acyl coa, one is that it can be used for triacylglycerol.
