Biology 2581B Final: Genetics 2581 Final Notes
18 Apr 2017
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Chromosomal rearrangements can occur on a large and small scale and include: Mouse versus human genome - at the sequence level they"re very similar and they have the same types of genes and their genes have similar sequences. However, at the chromosome level, when you compared the staining patterns of the chromosomes, there was no conservation suggested. But the mouse chromosome could be pieced together from putting together different human ones. Orientation of transcription (cid:314) almost the same: so basically they have the same types of genes, order and even their order of transcription is relatively the same, but they"re in different locations. You can take different genomes from grass and then line up the chromosomes as circles and you can see how they align - there are very few gaps. Can co-align them but there also has to be rearrangements occurring.
