BIO 1140 Lecture Notes - Lecture 12: G Protein–Coupled Receptor, Adrenergic Receptor, Phosphodiesterase

• School: University of Ottawa
• Department: Biology
• Course: BIO 1140
• Professor: Caroline Petit- Turcotte

Document Summary

Must be able to integrate all topics into one nice story. Growth factors will bind to each monomer of the receptor and the receptors will dimerize. -the dimer auto-phosphorylates; this is crucial and tract receptors are not active until this happens. -they need this (phosphorylated tyrosines) to interact with various proteins to relay the message. It does not have an sh2 domain these are key, must have the specific shape in the protein to interact. Grp2 has an sh2 domain, which comes with sos. -when ras is inactive, it binds with gdt, and binding to sos reduces the affinity for gbt and increases it to gtp. It"s a(cid:272)ti(cid:448)e a(cid:374)d it (cid:272)a(cid:374) (cid:374)o(cid:449) do its jo(cid:271) as a se(cid:272)o(cid:374)d (cid:373)esse(cid:374)ger a(cid:374)d a(cid:272)ti(cid:448)ate downstream affecters (proteins that carry messengers) -the bridge proteins are still functional, can attract and bring more ras, all with the same 2 ligands.