BIOL 1000 Lecture Notes - Lecture 31: Spindle Apparatus, Centrosome, Cytokinesis

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Lomoar cpsd| 987298: cytokinesis begins before mitosis ends, cytoplasm is divided in 2. Combination of 2 phases produces 2 genetically identical daughter cells. Cell division is a continuum of dynamic changes. Usually but not always followed by cell division (cytokinesis) Mitotic spindle = a football-shaped structure of microtubules that guides the separation of the 2 sets of daughter chromosomes . Spindle microtubules emerge from 2 centrosomes ( microtubule organizing centres ) = clouds of cytoplasmic material that contain 2 pairs of centrioles. Period of cell growth, cell synthesizes new molecules/organelles. By g2 cell has doubled its contents and cytoplasm contains 2 centrosomes, each centrosome with a pair of centrioles. Chromatin becomes tightly coiled in nucleus, forming discrete chromosomes (can be seen with light microscope) Each duplicated chromosome appears as 2 identical sister chromatids joined at the centromere. Mitotic spindle begins to form (microtubules grow out of centrosomes)

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