NURS 2050 Lecture Notes - Heparin-Induced Thrombocytopenia, Vitamin K Antagonist, Factor X
11 Apr 2013
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Purpose: prevent formation of growing of thrombi or help the body while it works to dissolve formed thrombi. Antiplatelets: cyclooxygenase inhibitors (e. g. asa, adenosine diphosphate (adp) receptor antagonists (e. g clopidogrel, glycoprotein iib/iiia receptor antagonists (e. g. abciximab, eptifibatide, tirofiban) Anticoagulants: vitamin k antagonists- (e. g. warfarin- a. k. a. Coumadin: factor xa and thrombin (iia) inhibitors- (e. g. heparin) Monitoring inr (pt ratio multiplied by a correction factor) - outpatient monitoring of. Drugs can: increase effects of warfarin, promote bleeding. Decrease the effects of warfarin, potentially lead to thromboembolic events: given po when possible, factor xa and thrombin (iia) inhibitors- heparin. Factors iia (thrombin), xa, ixa, xia, xiia. Factors iia and xa are the most responsive to inhibition. (heparin - anti iia > anti-xa activity). Adme & other considerations: not absorbed (polarity and size) iv infusion and sc, does not cross placenta, can bind to other tissues and proteins. M,e undergoes metabolism and renal excretion: t1/2 1. 5 hours (organ dysfunction = prolonged t1/2)
