PCL102H1 Lecture Notes - Droperidol, Morphine, Chlorpromazine
Document Summary
Funny thing about schizophrenia is that you"re blocking d2 in treatment, which you might expect to get either hyper or hypokinesia, but often you get both. This is a strange thing about these basal ganglia disorders. It"s a toxin that was accidentally produced in designer drugs and it caused a lot of parkinsonian symptoms in a lot of young people. 6 ohda has to be taken up by neurons and metabolized into something, and metabolite kills them. With extrapyramidal disorders, often trying to increase dopamine or decrease dopamine levels. With parkisonsons disease, the problem is too little dopamine, and want to increase it. So they give l-dopa, which is the precursor. Get good relief in initial few years of treatment. This would be something that would send down synthetic pathway for da and ne. so it would lower them both together. It"s a tyrosine hydroxylase inhibitor. benserazide (blocks peripheral.
