LMP299Y1 Lecture Notes - Alpha Beta Gamma, Interferon Gamma, Tumor Necrosis Factor Alpha
3 Jun 2013
School
Department
Course
Professor
Document Summary
Two major effective arms of immune system = t cells, b cells. Thymus made up of seven pairs of thymic lobes in avian, where t cells would mature and differentiate. In mammalian system, in pair of lobes in thymus. For b cells, in avians bursa fabricious but no equivalent invagination in intestines in mammalian cells bone marrow. Antigen sensitive cells have cell surface side chains (now called receptors) Error: b cells express receptors of one specificity other antigens cannot stimulate the cell to produce more antibodies. B-cell ig receptor green antigen interacting with b cell. Cell cell interactions hen cells collide, through receptors, recognize the type of cells interacting with. Carboxyl terminal anchoring the ig molecule on the cell surface. In circulating ig, there are intrachain disulfide bonds linking the two heavy chains, so they do not come apart but in cell-surface ig receptor, they are already anchored, so do not need intrachain disulfide bonds.
