BIOC63H3 Lecture Notes - Lecture 10: Cardiogenic Shock, Hypovolemia, Vasodilation

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14 Oct 2011
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Although the term shock is used by the layman to describe a psychological state, clinically it refers to an acute condition where cardiac output is insufficient for adequate perfusion of the tissues. The patient appears pale with cold skin, a weak pulse, and rapid shallow breathing. Urine output is reduced, and the blood pressure is generally low. Circulatory shock may be caused by a reduced blood volume (hypovolemic shock), profound vasodilatation (vasogenic shock), failure of the heart to maintain output due to cardiac disease (cardiogenic shock), or loss of vascular tone (neurogenic shock) (figure 1). Blood loss (hemorrhage) is a common cause of hypovolemic shock, and will be used to demonstrate compensatory mechanisms. Loss of up to ~10% of total blood volume does not elicit shock, as adequate perfusion can be maintained. If 20-30% of blood volume is lost, shock is normally induced and blood pressure may be depressed, although death is not common.

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