PHSL233 Lecture Notes - Bloating, Epidermal Growth Factor Receptor, Guanylyl Cyclase
24 Jul 2013
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This is signal transduction pathways of a stomach parietal cells which is a specilised epithelial cell. It secretes acidic fluid to stomach to aid with digestion. Secretagons are ligands or stimulatory agonist that will stimulate this pathway to release acid, histamine, acetylcholine and gastrin are the main ones. All agonist are working through gpcr, histamine is working through adenylyl cyclase whereas ach and gastrin are working through phosphatelipase c, but they all leading to the same acidic secretion effect. Vagal nerve stimulates enteric nerve which stimulates enterochromaffin cells (ecl) to release histamine. Closeby are parietal epithelial cells, histamine act on. H2 receptors (gpcr) on the basolateral membrane of the parietal epithelial cell. This activates the alpha-s subunit and in turn adenylyl cyclase is excited causing increase of camp and pka levels. Pka then phosphyorlates a h-k pump making a h-k -p pump.
