MELS223 Lecture Notes - Lecture 17: Nod2, Chemokine, Gout
6 Sep 2013
School
Department
Course
Professor
Document Summary
Immune response against peptide may be against self! Lactobacillus and e coli 0157:h7 looks the same. Foreign" pathogens must express molecules that mark them as foreign. Immune cells must be able to recognize these foreign" molecules. Activates genes for inflammatory cytokines, inflammatory chemokines. Pattern recognition receptors need to be all over bacterium (in and out) Receptor adaptor/scaffold proteins signaling proteins/second messengers (inhibitor unblockers) transcription factors genes proteins cells. Mincle recognizes malassezia spp and trehalose dimycolate from m tb. More nod in epithelial cells sites of infection. Nod also in apcs strengthens tlr signals. Link between prr and transcription = inflammasome. Stranger danger activation of complex of signaling molecules inside cell. Caspase 1 involved cleaves pro- il-1 and pro il-18. Stress, cell death, crystal salts, drugs danger signal. Translate external foreign and danger signals into inflammatory mediators. Il-1r alpha antagonist is used to treat gout block il-1 signals from those affected cells. Il-1 not present to cause inflammation but lose il-17.
