MIMM 214 Lecture Notes - Lecture 3: T Cell, Thymus, B Cell
7 Jun 2018
School
Department
Course
Professor
Lecture 3 – January 9, 2017
Innate Response
Breach of the epithelial cell layer
- Skin, gut
- Cells that detect
Pathogen Recognition
- TLRs, PAMPs
- Recognize pathogen
Sensor cells express pattern recognition receptors
- Pattern recognition receptors (PRRs) provide initial discrimination between self and non self
- PRRs recognize broad categories of molecules that are commonly found in pathogens (pathogen
associated molecular patterns – PAMPs)
Pathogen detection leads to activation of sensor cells
- Dendritic cells play key role
- Detect pathogens using receptors (PRRs)
- This detection leads to DC activation
Innate cell activation & local inflammation
Inflammation triggered by initial detection of pathogens
- Sensor cells induce an inflammatory response by producing mediators such as chemokines and
cytokines
- Redness, heat, swelling, and pain are hallmarks of inflammation
- Macrophage can release these molecules
- Ex: molecules can increase permeability of blood vessel to facilitate recruitment of other
immune cells to tissue
Dendritic cells link innate & adaptive immunity
- DCs travel from site of infection to local lymphoid system
- In Lymphoid tissue, they interact and activate T cells
T & B cell activation
APCs activate T cells through 3 crucial signals
- Key take home messages for now:
o Antigen presenting cells activate T cells
o Activation happens through 3 signals
▪ Through interaction of specific molecules (receptors and cytokines)
▪ Activation, Survival, Differentiation
o Happens in lymphoid tissue
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Pattern recognition receptors (prrs) provide initial discrimination between self and non self. Prrs recognize broad categories of molecules that are commonly found in pathogens (pathogen associated molecular patterns pamps) Pathogen detection leads to activation of sensor cells. Sensor cells induce an inflammatory response by producing mediators such as chemokines and cytokines. Redness, heat, swelling, and pain are hallmarks of inflammation. Ex: molecules can increase permeability of blood vessel to facilitate recruitment of other immune cells to tissue. Dcs travel from site of infection to local lymphoid system. In lymphoid tissue, they interact and activate t cells. Apcs activate t cells through 3 crucial signals. Key take home messages for now: antigen presenting cells activate t cells, activation happens through 3 signals, through interaction of specific molecules (receptors and cytokines, activation, survival, differentiation, happens in lymphoid tissue. An antigen is any specific molecule that can trigger an immune response (mostly protein)
