NROC69H3 Lecture Notes - Lecture 3: Cable Theory, Axon Hillock, Backpropagation
Document Summary
Lecture overview synaptic integration temporal and spatial summation factors that affect dendritic synaptic integration. Back propagation of action potentials inhibitory influences. Beyond neurotransmission: concept of bidirectional information flow, extrasynaptic neurotransmission, neuromodulation. Unlike a muscle fibre that receives 1 excitatory input from 1 motor neuron, the majority of central neurons receive inputs from hundreds of neurons which can be both excitatory and inhibitory. Traditional view of synaptic integration synaptic integration results from simple algebraic summation near the soma, with dendrites as mere conduits delivering synaptic potentials to the site of integration. Primary function of the dendritic tree is to collect and funnel information received at individual synapses to the soma and axon ramon y cajal. Dendrites are principal sites for synaptic input: spines on the dendrites are important in the consolidation of memory. Temporal and spatial summation temporal: algebraic sum of epsps that arise close in time spatial, algebraic sum of epsps from different areas of input.
