BIOL303 Lecture Notes - Blastoderm, Antennapedia, Zygote
28 Oct 2013
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Biol 303 study questions set 7: the kruppel gene is expressed in a single broad stripe in the mid region of the. Gap genes: mutants lack large regions of the body several contiguous segments. Where we see expression of gap gene in mutant is exactly where we see that part of the body deleted. Gap genes include hunchback, giant, knirps and kruppel. These genes are dna binding proteins, short lived. Initial pattern of gap gene expression is stabilized by repressive interactions between different gap genes gap gene expression can overlap but there is strong mutual repression between pairs of nonadjacent gap genes. Depending on concentration, hunchback may either repress (when high) or activate (when low) the expression of kruppel. Bicoid mutant only has maternal hunchback protein. Pair-rule genes: pair rule gene expression establishes the segmental body plan. Primary pair-rule genes depend on maternal and gap transcription factors for its activation. Secondary pair-rule genes: primary pair-rule genes influence expression.
