BIO200H5 Lecture Notes - Lecture 17: Partial Agonist, Beta Blocker, Nalorphine
Document Summary
On the counter - aspirin like drugs, cough syrup. Herbal - induce liver, even though not much therapeutic effect. When two drugs work on the mechanism of action, on the same receptor. Ex: apply morphine and antagonist at the same time compete for same receptor. Doesn"t cause any physiological change at receptor level; can cause. Morphine - full agonist; nelorphine has much lower analgesic activity, a partial agonist. Not common, has physiological effect but effect is opposite from what you would expect. Diazepam - binds to benzodiazepine receptor full agonist; increase cl floods. Effect of one drug is added to the effect of other drug. If you take beta - blockers at the same time, additive - this is often what we see. Help each other"s effect, drugs that work at different receptors. Combine 2 less effect, they counteract one another. Works with gaba h channel and gaba a channel but binds to different site.
