KINE 4370 Lecture Notes - Hindbrain, Somite, Notch 1
5 Dec 2013
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Document Summary
Two thirds of all gene expression occurs for the brain. The age of the embryo in weeks has critical times (purple portion before). Schizophrenia involves the early period of development of the nervous system, there are critical stages. The critical period, myelination is out of balance, which causes schizophrenia. At the early blastula stage early in development, it is a cell mass, has a polarity, has endoderm, and mesoderm. The animal pole has more proliferation versus the vegetal pole. Neurulation occurs at 18 days neuroectoderm, notochord (which develops into spinal cord and releases factors that effects differentation), primitive streak, which is the early nervous system. At day 20, the cells are more differentiated, the neural crest form, which is the early pns. The floorplate= base of the ns, and the somites =muscular system is formed as well. At 22 days roofplate is found, neural crest is separated.
