CSB325H1 Lecture Notes - Lecture 3: Paracrine Signalling, Endocrine System, Endocrine Gland
18 Dec 2013
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Document Summary
In the last 30 years advent of information theory was applied to endocrinology endocrinology and signaling molecules became associated with the transfer of information from one tissue or cell to another tissue or cell. Endocrinology involves homeostasis, cell signaling, communication, and information transfer. Hormone is one type of signaling molecule that is released by a tissue into the blood stream and interacts with another tissue. However, hormone is frequently considered to be synonymous with signaling molecules. Autocrine: a chemical released from a cell binds to a receptor on the same cell or an identical cell to modulate the activity of that cell. Paracrine: a chemical released from a cell binds to a receptor on a different type of cell. Juxtacrine: between two cells or the cell and the extracellular matrix. Membrane-bound ligand binds to membrane-bound receptor: e. g. , delta (ligand) binds to notch (receptor) Components of the ecm binds to membrane-bound receptor.
