BIO230H1 Lecture Notes - Lecture 9: Tyrosine Kinase, Sh2 Domain, Sh3 Domain
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BIO230H1 Full Course Notes
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We saw how small molecules interacted with proteins. Small molecules , they interacted through non covalent interactions. Changed the structure of the protein through downstream signaling. 60 encoded in human genome some bind to secreted proteins. They bind to different ligands on the ec surface. There is a large variation if you look across. We can hypothesize that they will be binding to different ligands in extracellular space. Can send signal from extracellular space to intracellular space into the cytoplasm. If we look at the cytoplasmic tails of their proteins they all have a common domain, tyrosine kinase domain. Different signals in the outside but feeding into the tyrosine kinase signal from the inside. All of the details in the table is not critical. The theme as we look across the information. The name of the signaling protein and various growth factors. In response to the signaling there are stimulations of:
