PSYC 3030 Lecture Notes - Lecture 5: Peripheral Nervous System, Isoleucine, Sumatriptan

• School: University of Guelph
• Department: Psychology
• Course: PSYC 3030
• Professor: Rob Foster

Document Summary

A serum factor in the gastrointesanal tract capable of producing vasoconstricaon (1930) Sero (from serum) tonin (a ecang muscle tone) Found is serum gastrointesanal tract of leeches, scorpions, lobsters . 90% in the gastrointesanal system. 8% in blood platelets (used during clopng process) 2% in the central nervous system (pineal gland: for the producaon of melatonin) Lysergic acid diethylamide (lsd; 1953) antagonizes the contracale e ect of serotonin on smooth muscles. Tryptophan hydroxylase (th) is the rate- limi)ng enzyme. Synthesized in 5- ht nerve cell bodies (cellular marker of. 5- ht neurons) and transported to the nerve terminal by axonal transport. Try h acavity is primarily regulated by neuronal ring through depolarizaaon- induced phosphorylaaon of ca+/ calmodulin- dependent protein kinase ii (cam- k ii) 5- ht synthesis occurs in the nerve terminal. Tryptophan is an essenaal amino acid derived from diet (animal & plant proteins) Also, a low- protein but rich carbohydrates meal can signi cantly increase brain 5- ht.