BIOL 314 Lecture Notes - Pleiotropy, Hydrolysis, N-Formylmethionine-Leucyl-Phenylalanine
27 Feb 2014
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Document Summary
When a cell receives an extracellular cue which it transduces into the cell to affect intracellular signaling pathways. A cell-free filtrate held to be a virus that is responsible for a specific neoplasm in humans or animals. A virus may be tumor forming depending on species (cold virus causes tumor in mice). Active site closed (inaccessible to tyrosine residues) dephosphorylates y527. Tyrosine kinases phosphorylate y416 in active site (increases src kinase activity) Kinase domain is constitutively active in the absence of external mitogenic stimuli. v-src is an oncogene. Highly associated with the mammary gland, but does not depend on pregnancy/lactating. Facilitates experiments on the mammary-epithelial specific expression of genes in transgenic mouse models. Induces fast transformation by recruiting c-src and keeping it active. Src phosphorylates 2 tyrosine, activating pl3 kinase & ras. Induced by dna damage or viral infection that blocks cell cycle progression (g1 or g2) until dna is repaired or it induces apoptosis of virally infected cells.
